Aims/Hypothesis: Beta-cell failure plays a fundamental role in type 2 diabetes mellitus (T2DM) development. It has been shown that the beta-cells are among the most sensitive to hypoxia. We aimed to ...

In recent years, we have come to appreciate that loss or dysfunction of insulin-producing islet beta cells underlies virtually all major forms of diabetes mellitus. In type 1 diabetes, beta cells ...

The study's findings could lead to earlier detection and intervention of insulin resistance, prediabetes and Type 2 diabetes, ...

Researchers have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity - a harmful condition linked to the progression of type 2 ...

A study led by researchers at Stanford Medicine has shown that differences in blood sugar responses to certain carbohydrates depend on details of an individual’s metabolic health status, including ...

The weekly combination therapy is intended for adults with poor glucose control despite basal insulin or GLP-1 receptor ...

Biomea Fusion, Inc. has presented promising clinical results for icovamenib, a novel therapy aimed at restoring beta-cell function in patients with type 2 diabetes, at the ATTD 2025 Conference.

Therapeutic effects were sustained off treatment, with persistent reduction in HbA1c and improvement in beta-cell function 3 months after last dose, suggesting disease-modifying potential of ...

Many individuals are told that managing type 2 diabetes is simply a matter of controlling blood sugar. As long as glucose levels fall within a target range, they are often reassured that everything is ...