In patients with acidemia, hypobicarbonatemia conferred a considerable risk of kidney failure requiring renal replacement therapy after adjusting for potential confounders. Incorporating venous pH ...

Prior low-quality evidence has suggested that sodium bicarbonate may benefit critically ill patients with severe metabolic acidemia and acute kidney injury (AKI). In this randomized trial of patients ...

A 70-year-old woman is admitted to the intensive care unit (ICU) with a pH of 7.1, an acute kidney injury (AKI), and ketonuria. She is volume depleted and her history is consistent with starvation ...

urine sample Oral sodium bicarbonate therapy given to patients with chronic kidney disease increases urinary pH but also increases urinary citrate levels, which may mitigate the risk for calcium ...