Oxidative decarboxylation of pyruvate to form acetyl–coenzyme A, a crucial step in many metabolic pathways, is carried out in most aerobic organisms by the multienzyme complex pyruvate ...

PYRUVATE DEHYDROGENASE COMPLEX . Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in ...

Glycolysis, Pyruvate Oxidation and the Krebs Cycle Glycolysis, the process of splitting a six-carbon glucose molecule into two three-carbon pyruvate molecules, is linked to the Krebs cycle.

This intermediate subsequently undergoes decarboxylation to release carbon dioxide. The first few steps are common to all the members of the pyruvate oxidase (PO)-like subfamily.