Figure 3: d-Asb11 binds to the Notch regulator Nrarp and the Notch ligand DeltaA. Figure 5: Activation of Notch reporters by d-Asb11 requires other cells (a) When d-Asb11 was overexpressed in the same ...

A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...