In living organisms, there are many chemical reactions taking place. These reactions have many different functions, including breaking down the food we eat and getting energy from the broken down food ...

The trace element molybdenum is essential for nearly all organisms and forms the catalytic centre of a large variety of enzymes such as nitrogenase, nitrate reductases, sulphite oxidase and xanthine ...

Little is currently known about the molecular determinants of energy barriers along enzyme catalytic pathways. Kern and co-workers have studied this question in adenylate kinase (Adk) and now reveal ...

Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide (phosphate) (NAD(P)) presents challenges due to its high consumption and ...

The snapshots reveal key reactions steps. At 0 ms, water molecules occupy the substrate-binding site. At 50 ms, a substrate-cofactor intermediate forms. At 100 ms, the product is released, and the ...

Cells use flavin monooxygenases to break down foreign molecules by adding oxygen atoms to them. Biochemists have long assumed that the enzymes use a particular cofactor adduct to add the oxygen. A new ...

Researchers have engineered a hydrogen-producing enzyme in the test tube that works as efficiently as the original. The protein – a so-called hydrogenase from green algae – is made up of a protein ...

Enzymes help with specific functions that are vital to the operation and overall health of the human body. They help speed up chemical reactions and are essential for respiration, digestion, muscle ...