MedPage Today

NSCLC: Structure-Function Relationship of EGFR Exon 20 Insertion Mutations

Activating mutations on the EGFR protein, including exon 20 insertion mutations, have a role in NSCLC, but the associated structural changes resulting from the V769insASV and D770insNPG EGFR exon 20 ...
Nature

Deletion and Insertion Mutations in Short Tandem Repeats in the Coding Regions of Human Genes

In vitro studies in bacterial, yeast and eukaryotic systems have demonstrated the existence of deletion and insertion ‘hotspots’ involving repetitive sequences. Slipped-strand mispairing (SSM) has ...
The American Journal of Managed Care

City of Hope’s Afkhami Discusses NSCLC With EGFR Exon 20 Insertion-Positive Mutations

Michelle Afkhami, MD, of City of Hope, joins The American Journal of Managed Care® (AJMC®) for a discussion on EGFR exon 20 insertion positive mutations in non-small cell lung cancer. Michelle Afkhami ...
MedPage Today

In NSCLC, Response to ICIs Is Influenced by EGFR- and HER2-Mutant Subtypes

“The goal of our study was to investigate the influence of HER2 and uncommon EGFR mutation subtypes and their clinical outcomes in patients treated with ICIs compared to canonical EGFR sensitizing ...
Cure Today

Drug Targeting Offers Hope for Patients with Non-Small Cell Lung Cancer that Harbors Rare Mutations

After Robin Kwiecien was diagnosed with non-small cell lung cancer (NSCLC) in 2018, she started a course of targeted radiation, which kept the disease under control for nearly two years. When the ...