ESPN Analytics has revealed its Matchup Predictor numbers for the 16 games in the league this week, and they offer some interesting win probabilities.

NFL Week 18 betting spreads, lines, point totals for every game on NFL Week 18 schedule, with odds for favorites and underdogs in each NFL matchup.

It all comes down to this. There is only one week remaining in the 2025-26 NFL regular season, with two playoff spots on the line. There is one spot up for grabs in the AFC and one in the NFC, with both games determining those positions set to be highlighted in Week 18.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Week 18 action kicks off with a Saturday doubleheader, however, which features the Carolina Panthers at the Tampa Bay Buccaneers at 4:30 p.m. ET on ESPN/ABC, and the Seattle Seahawks at the San Francisco 49ers at 8 p.m. ET on ESPN/ABC.

NFL football continues with Week 17. Who plays NFL games today? What is the NFL TV schedule? See every NFL game's start time and how to watch this Sunday.

How to watch NFL Week 16 games on television this week, including schedule, dates, times, matchups, TV channels, streaming information for every game.

Fifteen of the top 18 picks in the 2026 NFL Draft order changed hands in Week 17, including the No. 1 overall selection. Dan Parr runs through Round 1 and highlights each squad's five biggest needs.