Later we comment on the metabolic pathways in which the three classes ... promoted the oxidation of a much higher amount of pyruvate, suggesting a catalytic effect of these compounds.

pyruvate metabolism. Most genes involved in these metabolic pathways were downregulated during sarcopenia progression. For example, the expression of branched-chain amino acid transaminase 2 ...

This shift underscores the potential for targeting specific metabolic pathways in cancer treatment ... liver tumorigenesis through indole 3-pyruvate synthesis, Nature Communications (2024).

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.