Over a decade ago, a group from the Section of Dialysis and Extracorporeal Therapy at The Cleveland Clinic, OH, developed a bicarbonate-based dialysate for use during continuous renal replacement.

a significant deterioration in renal function was observed in the standard-therapy group. Two hours after contrast injection, patients who received sodium bicarbonate exhibited elevated serum pH ...

and excessive renal bicarbonate loss due to compensation for a preceding period of hypocapnia and respiratory alkalosis. [12,13,14] Acidosis produces myocardial depression, reduces the ...