Over a decade ago, a group from the Section of Dialysis and Extracorporeal Therapy at The Cleveland Clinic, OH, developed a bicarbonate-based dialysate for use during continuous renal replacement.

RTA is a condition in which there is a defect in renal excretion of hydrogen or reabsorption of bicarbonate, or both, out of proportion to impairment of glomerular filtration. It is suggested that ...