HOW Does 6-PPDQ disrupts the citric acid cycle in caenorhabditis elegans. FAYETTEVILLE, GA, UNITED STATES, July 2, 2025 /EINPresswire / ...

The FDA has accepted for Priority Review the NDA for SL1009 to treat pyruvate dehydrogenase complex deficiency.

Acetyl-CoA is regulated by the controlled amounts of pyruvate that is converted into acetyl-CoA in the pyruvate dehydrogenase complex reaction.

The study found that among the genes encoding components of the pyruvate dehydrogenase complex, which controls acetyl CoA synthesis, only dlat-1 and dld-1 expressions were decreased by 6-PPDQ.

The authors highlight that the acetyl-CoA synthase does a complicated molecular choreography, rearranging and interacting with partner molecules in the cell, to be able to make acetyl-CoA.

A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight ...

Metabolism comprises of two major parts: anabolism and catabolism. Catabolism is the set of metabolic processes that break down large molecules. These more complex molecules are broken down to ...

Acetyl-CoA carboxylase (ACC) is an enzyme with two isoforms (ACC1 and ACC2) that is involved in de novo lipogenesis (the synthesis of endogenous fatty acids) and the regulation of beta-oxidation ...