Gut

Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD

Background Concomitant metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in patients with chronic ...
Gut

Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers

Background Gut microbiota dysbiosis is linked to autism spectrum disorder (ASD) in children. However, the role of bacterial ...
gut.bmj

Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients

Correspondence to Hjalmar C van Santvoort, Department of Surgery, Dutch Acute Pancreatitis Study Group, University Medical Center Utrecht 3508 GA/ St. Antonius Hospital Nieuwegein 3435 CM, The ...
gut.bmj

KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy

Background CLDN18.2 has emerged as a promising therapeutic target in gastric and gastro-oesophageal junction cancers. However, its clinical efficacy in pancreatic ductal adenocarcinoma (PDAC) has been ...
gut.bmj

Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial

Correspondence to Dr Michael J Bourke, Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead 2145, New South Wales, Australia; michael{at}citywestgastro.com.au Background and aims ...
gut.bmj

Quality of life measurement in gastrointestinal and liver disorders

Conflict of interest statement.Professor Irvine shares ownership of the copyright, together with McMaster University, of the Inflammatory Bowel Disease Questionnaire (IBDQ). Modern medicine has had a ...
gut.bmj

Proton pump inhibitors alter the composition of the gut microbiota

Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux. They have been considered low ...
gut.bmj

Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites

Correspondence to Professor Jun Yu, Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; ...
gut.bmj

Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

3 NHS Bowel Cancer Screening Midlands and North West Programme Hub, Rugby, UK 4 NHS Bowel Cancer Screening Southern Programme Hub, Guildford, UK 5 University of Surrey, Guildford, UK Correspondence to ...
gut.bmj

IDDF2024-ABS-0273 LCN2 promotes ferroptosis and induces impairment of intestinal barrier function in ulcerative colitis by regulating ALOX15-mediated lipid peroxidation

Background Ulcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract that affects the rectum and colon. Ferroptosis is a type of cell death that is triggered by an excess of ...
gut.bmj

IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these ...

Objective The interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes in these therapeutic trials ...
gut.bmj

Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis

4 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA Correspondence to Dr Siddharth Singh, Division of Gastroenterology and ...