Telomerase promotes proliferation of resting stem cells through a mechanism that does not involve the extension of chromosomal telomeres, researchers report in Nature this week. "This is a completely ...

More recently, researchers have found that telomerase's lifespan-extending activity is switched on in many types of cancers. To search for a second telomerase function, Smith and Coller added an ...

Telomerase has functions other than elongating telomeres. 11 For example, telomerase overexpression in adult mice mobilizes stem cells and induces stem-cell proliferation in the absence of ...

Researchers discover unprecedented pathway in edible fungus that produces telomerase RNA from a protein-coding messenger RNA.

In an effort to understand and control telomerase activity, researchers have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts ...

Biochemists have produced a three-dimensional structural model of telomerase's RNA "core domain." Telomerase is an enzyme that helps maintain telomere DNA -- the DNA found at the very ends of ...

Researchers at UC Santa Cruz have determined the structure of a key part of the enzyme telomerase, which is active in most cancers and enables cancer cells to proliferate indefinitely. The new ...

Cao and her colleagues suspected telomerase may have a function in adult cells when they observed dramatic differences in the laboratory among sibling mice with shortened telomeres. The mice were ...

Telomerase: a biochemical relic? While Blackburn focuses her research on the ways in which telomeres function and on what factors influence their specific behaviors, she also is fascinated with the ...

In an effort to understand and control telomerase activity, researchers at the Wistar Institute have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase ...

It is therefore the incomplete function of the spliceosome — as measured by mRNA-production standards — that is needed for the formation of telomerase RNA.

The debate continues as to whether telomerase's only function is to promote telomere extension. In recent years evidence has suggested that the enzyme promotes cancer development and might have roles ...