Europe PMC

Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an ...

Despite recent progress in antithrombotic therapy, there is still an unmet medical need for safe and orally available anticoagulants. The coagulation enzyme Factor Xa (FXa) is a particularly promising ...
Europe PMC

Indian Academy of Pediatrics Revised (2021) Guidelines on Prevention and Treatment of Vitamin D Deficiency and Rickets.

The emerging literature on prevalence of vitamin D deficiency in India, prevention and treatment strategies of rickets, and extra-skeletal benefits of vitamin D suggest the need for revising the ...
Europe PMC

Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial.

Rosmarinus officinalis L. is a medicinal plant with diverse activities including enhancement microcapillary perfusion. The present study aimed to investigate the clinical efficacy of rosemary oil in ...
Europe PMC

Direct Use of Clinical Tolerance Limits for Assessing the Degree of Agreement between Two Methods of Measuring Blood Pressure.

A large number of new methods of measuring blood pressure (BP) have recently emerged with advances in technology. Different methods of measuring BP generally provide varying readings compared with one ...
Europe PMC

Triterpene acids from Toddalia asiatica

Triterpene acids from Toddalia asiatica Four new triterpene acids,2#alpha#,3#alpha#, 19#alpha#-trihydroxy-11-oxo-urs-12-en-28-oic acid (1) ,2#alpha#,3#alpha#, 11#alpha#, ...
Europe PMC

Co-movement and Lead–Lag Relationship Between Green Bonds and Renewable Energy Stock Markets: Fresh Evidence from the Wavelet-Based Approach

Co-movement and Lead–Lag Relationship Between Green Bonds and Renewable Energy Stock Markets: Fresh Evidence from the Wavelet-Based Approach ...
Europe PMC

Cancer statistics for the year 2020: An overview.

Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open ...
Europe PMC

Review of Effects of Dam Construction on the Ecosystems of River Estuary and Nearby Marine Areas

Dams have made great contributions to human society, facilitating flood control, power generation, shipping, agriculture and industry. However, the construction of dams greatly impacts downstream ...
Europe PMC

SARS-CoV-2 S1 Protein Persistence in SARS-CoV-2 Negative Post-Vaccination Individuals with Long COVID/ PASC-Like Symptoms

SARS-CoV-2 S1 Protein Persistence in SARS-CoV-2 Negative Post-Vaccination Individuals with Long COVID/ PASC-Like Symptoms ...
Europe PMC

The Endeavor to Predict Depression and Anxiety Trajectories in the Context of Chronic Diseases Remains a Formidable Challenge.

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Europe PMC

TnpB structure reveals minimal functional core of Cas12 nuclease family.

The widespread TnpB proteins of IS200/IS605 transposon family have recently emerged as the smallest RNA-guided nucleases capable of targeted genome editing in eukaryotic cells 1,2. Bioinformatic ...
Europe PMC

Single-cell RNA-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells

Gene expression and its regulation can be context-dependent. To dissect this, using samples from 120 individuals, we single-cell RNA-sequenced 1.3M peripheral blood mononuclear cells exposed to three ...