Mammalian cells have enzymes to convert adenosine to inosine by deamination and inosine to hypoxanthine by phosphorolysis, but they do not possess the enzymes necessary to form the free base, adenine, ...

Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Excessive activation of PARP-1 by cellular insults ...

Some of the elements necessary to support life on Earth are widely known - oxygen, carbon and water, to name a few. Just as important in the existence of life as any other component is the presence of ...

RNA is a single stranded molecule containing a ribose sugar. It has a distinctive structure and, unlike DNA, there are variations and various types of RNA structures. A base is attached to the 1' ...

Scientists have developed and improved the ABE system in mouse and rat strains, which has great implications for human genetic disorders and gene therapy. Two research teams from East China Normal ...

Nucleotides are the fundamental units that make up the genetic material of all living organisms. They are the building blocks of DNA and RNA, which store and transmit genetic information. Nucleotides ...