A year after undermining Bredt's rule, scientists make cage-shaped, double-bonded molecules that defy expectations

Organic chemistry is packed with rules about structure and reactivity, especially when it comes to making and breaking ...

Bis-pseudoindoxyls: A new class of single benzene-based fluorophores for bioimaging applications

Fluorophores are chemical compounds or molecules that absorb light energy at one wavelength and re-emit it as light at a ...
C&EN

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Article Views ...
C&EN

Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors

Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States ...
Morning Overview on MSN

100-year-old chemistry law debunked, forcing textbook rewrites

A cornerstone rule of organic chemistry that has guided students and researchers for a century has just been shown to be wrong in a key way. By deliberately building molecules that were long ...
Scientific Research Publishing

Photochemical Cycloaddition as a Gateway to Bicyclic Lactones: Toward Tricyclic Iridoid-Inspired Scaffolds ()

A photochemical [2+2] cycloaddition between cyclopentene-1-one and 1,1-dimethoxyethylene was effectively utilized to synthesize a key bicyclic intermediate in the preparation of tricyclic ...