Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

CAMBRIDGE, Mass., Feb. 13, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase ...

Background: Isoenzyme type M2 pyruvate kinase (M2-PK) can only be detected in gastrointestinal (GI) tumors. Detection of M2-PK on a small, portable platform with minimal training required, could offer ...

4 Department of Pathology, Cruces University Hospital, Barakaldo, Spain 5 Ikerbasque, Basque Foundation for Science, Bilbao, Spain Background: Pyruvate dehydrogenase (PDH) complex converts pyruvate ...

Visual Abstract Mitapivat vs. Placebo for Pyruvate Kinase Deficiency DOI: 10.1056/NEJMdo006520 Save ...

The Food and Drug Administration (FDA) has approved Pyrukynd ® (mitapivat) for the treatment of hemolytic anemia in adults with pyruvate kinase deficiency. Pyruvate kinase (PK) deficiency is a ...

Decision letter after peer review: Thank you for submitting your article "Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria" for ...

Likewise, the reductive power generated by the oxidative decarboxylation of pyruvate is wholly directed to NAD + without any side reaction or reactive oxygen species generation. E2p is part of a ...