Scientists found that brain cells can tap a hidden sugar stash to clean up the toxic proteins behind Alzheimer’s. By kick-starting an enzyme called GlyP, they reroute stored sugar into a protective ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

To determine tissue accumulation of 2-DOG-6-phosphate, 100–500 mg tissue was homogenized in 2 ml distilled water, and 1.6 ml of the homogenate was transferred to 1.6 ml 7% ice-cold perchloric acid.

Crystalline silica is well-known to induce oxidative stress as a consequence of both surface-derived generation of free radicals and intracellular production of reactive oxygen species upon ...

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

Truncated aminoglycoside−coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, ...