Every time a eukaryotic cell divides, it faces a monumental challenge: It must carefully duplicate and divide its genetic ...

Chromosomes continuously develop their shape during cell divisions. Mitotic chromosomes gradually shorten and thicken. Longer ...

Another protein central to this process is NuMA, which is essential for spindle pole organisation. Normally, NuMA gathers at ...

In 2000, researchers discovered that mutations that inactivate a gene known as TRIM37 cause a developmental disease called Mulibrey nanism. The extremely rare inherited disorder leads to growth delays ...

Mitotic kinase CDK1 phosphorylates LDHA at T18, reducing its incorporation into LDH tetramers and promoting formation of LDHB-enriched tetramers during mitosis. This accelerates lactate-to-NADH ...

The study will interest researchers studying genome organisation in mitosis. Genomes assume a complex 3D architecture in the interphase cell nucleus. Yet, the molecular mechanisms that determine ...

Until now, cells dividing by mitosis were thought to grow round and then split into two identical, spherical daughter cells. New research has found that some cells are isomorphic, meaning they retain ...

Figure 1: A light micrograph of a large oocyte in an ovary. RIKEN researchers have found that MPS1 promotes timely spindle bipolarization when oocytes in mice undergo ...