Amgen’s AMG 193 Study: A New Hope for Advanced NSCLC Treatment?

The intervention being tested is AMG 193, an experimental drug administered orally in film-coated tablet form. The purpose of AMG 193 is to treat MTAP-deleted NSCLC by evaluating its safety and ...
C&EN

Postmortem Changes in Pork Muscle Protein Phosphorylation in Relation to the RN Genotype

§ Department of Food Science, Swedish University of Agricultural Sciences, P.O. Box 7051, SE-750 07 Uppsala, Sweden ∥ Department of Clinical Sciences, Swedish University of Agricultural Sciences, P.O.
PNAS

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

Contributed by Vern L. Schramm, May 5, 2017 (sent for review March 23, 2017; reviewed by Jiali Gao and Nigel S. Scrutton) TPS calculations predicted that a F159Y mutation in PNP would facilitate ...
PNAS

Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells

Edited* by Carlo M. Croce, Ohio State University, Columbus, OH, and approved May 17, 2010 (received for review December 9, 2009) ...