A new study published in Nature Communications reveals a novel approach to mitigating tissue damage caused by Streptococcus pyogenes, the flesh-eating bacterium responsible for severe infections such ...

Animals, plants and many other living organisms inhale oxygen to "burn" (oxidize) compounds like sugar into CO2 and water—a process during which the energy-rich molecule ATP is produced. Cells require ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

Northwestern Medicine investigators have uncovered new insights into how metabolic dysfunction contributes to Parkinson's ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.

pyruvate metabolism. Most genes involved in these metabolic pathways were downregulated during sarcopenia progression. For example, the expression of branched-chain amino acid transaminase 2 ...

We have investigated cellular processes upstream of the mitochondrial functions and discovered that gp120 causes metabolic reprogramming. Effectively, the addition of gp120 protein to neuronal cells ...

Pyruvate and glyceraldehyde-3-phosphate are further assimilated through the glycolytic pathway (Supplementary Figure 1A). In addition, there are a few bacteria, such as Sphingomonas sp. strain A1, ...

Our study has its limitations. Our data provide a systematic snapshot of the effect of empagliflozin on highly relevant metabolic pathways of the whole organism but do not yield definitive mechanisms ...