Later we comment on the metabolic pathways in which the three classes ... promoted the oxidation of a much higher amount of pyruvate, suggesting a catalytic effect of these compounds.

The study also explored the impact of PDK1 Y163 phosphorylation on lung cancer cell proliferation, invasion, and metabolism. It was found that a phospho-dead mutation at Y163 abolished the ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of ...

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.

pyruvate metabolism. Most genes involved in these metabolic pathways were downregulated during sarcopenia progression. For example, the expression of branched-chain amino acid transaminase 2 ...

This shift underscores the potential for targeting specific metabolic pathways in cancer treatment ... liver tumorigenesis through indole 3-pyruvate synthesis, Nature Communications (2024).