Researchers determined the clinical classification of more than 90% of potential BRCA2 variants of uncertain significance in ...

Here we report that activation of poly(ADP-ribose) polymerase (PARP ... induced changes in high energy phosphates, pyridine nucleotide levels, eNOS activity and cell function in endothelial ...

NMN is a nucleotide derived from ribose and nicotinamide, a form of vitamin B3. Research indicates that NMN can elevate levels of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme ...

RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally ... guided by complementary pairing between nucleotide bases. Formation of biomolecular ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR) ...

and poly(ADP-ribose) polymerase 1 (PARP1) (146–148). Figure 3 Autophagy as a negative regulator of cGAS. cGAS is a cytosolic sensor for long cytosolic dsDNA fragments. Binding to long dsDNA fragments ...

The ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge CB2 0AH, U.K.

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