PHILADELPHIA -- An oral, non-addictive sodium channel blocker safely relieved moderate-to-severe acute pain following surgery, according to phase III data that could support regulatory approval.

Mutant Brown-Norway-Katholiek (muBN-Ka) rats are capable of producing kininogens in the liver, but cannot release them into the bloodstream, because of the point mutation of Ala163 to Thr in the ...

Praxis Precision Medicines has scored another midphase win in epilepsy this year, with its sodium channel inhibitor shown to reduce seizures in children with two specific types of the neurological ...

Inspired by the natural bonding between a class of potent local anesthetics called site-1 sodium channel blockers (S1SCBs) and peptide sequences on the sodium channel in the nerve cell membrane, ...

ATS 2009, SAN DIEGO—Cystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to ...

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and ...

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their ...

Figure 1: Results obtained with the five-step purification procedure, applied to MS and GBS CSF. Figure 3: Concentrations and effects of the natural factor and two synthetic peptides. Amidation of the ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

Allay Therapeutics has exited stealth armed with clinical pain data, cash from backers including NEA and plans to move its lead candidate into phase 2b this year. The lead candidate, ATX-101, consists ...