In a three-reaction sequence in liquid ammonia, an alkyl halide or sulfate reacts with sodium acetylide to form a terminal alkyne; the alkyne reacts with sodamide to form its acetylide; and that ...

Heath, Sharpless and co-workers synthesized the previously identified bivalent ligand, added a terminal alkyne and repeated the process. The result was a trivalent ligand with a K D of ≈ 50 nM ...