As the scientific community seeks sustainable solutions to reduce our carbon dioxide (CO 2) footprint, nature offers inspiration: in addition to photosynthetic carbon fixation, there are other natural ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

The other electron donor generated by the TCA cycle is FADH 2, formed by succinate dehydrogenase ... fatty acids and oxidation of FFA-derived acetyl CoA by the TCA cycle generate the same electron ...

β-Oxidation of acyl-CoA to acetyl-CoA then occurs at the matrix ... and very long-chain acyl-CoA dehydrogenase deficiency are especially prone to recurrent acute myalgia and rhabdomyolysis.14 Symptoms ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Acetyl-CoA synthetase (ACS) is one of several enzymes that generate the key metabolic intermediate, acetyl-CoA. In microbes and mammals ACS activity is regulated by the post-translational acetylation ...

Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Science Center for ...