Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

PHOSPHATE STARVATION RESPONSE 1 (PHR1) is a master transcription factor involved in the Pi starvation in A. thaliana.Under Pi starvation conditions, PHR1 binds to the PHR1‐binding site (P1BS) element ...

Intriguingly, single-cell transcriptome profiling of fetal gonads from both humans and mice shows that MCM8 is also highly expressed in PGCs undergoing rapid mitosis (Li et al, 2017; Niu and Spradling ...

Colorectal cancer stands as the second leading cause of cancer-related mortality worldwide and ranks third in global cancer diagnoses. Despite the efficacy of surgical resection and adjuvant ...