Researchers have found that proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research, could potentially lead to the ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Metabolic-dysfunction-associated steatotic liver disease (MASLD) arises from excessive intrahepatic triglyceride accumulation ...

Understanding these shared metabolic pathways opens new avenues for improving both crop resilience and human nutrition. The study focuses on lysine catabolism. Catabolism, the breakdown of ...

The activation of FGFR1 by KLX was confirmed through the observation of increased interactions between phosphorylated FGFR1 and MAP4K4, and the inhibition of this pathway by a FGFR1 inhibitor ...

An additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as ...

Related published literature focuses primarily on lipid metabolism, and observations about utilization of acetate as an energy source are incidental. The largest collection of existing literature in ...

Here, we describe a computational method that predicts the functions of orphan enzymes by organizing them into a linear metabolic pathway. Given candidate enzyme and metabolite pathway members, this ...

Acetyl CoA is generated from catabolic pathways of intermediary metabolism and at the same time used by anabolic processes such as lipid synthesis. In mammalian cells, there are three major enzymes ...

Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often ...