Organic chemistry is packed with rules about structure and reactivity, especially when it comes to making and breaking ...

A cornerstone rule of organic chemistry that has guided students and researchers for a century has just been shown to be wrong in a key way. By deliberately building molecules that were long ...

A photochemical [2+2] cycloaddition between cyclopentene-1-one and 1,1-dimethoxyethylene was effectively utilized to synthesize a key bicyclic intermediate in the preparation of tricyclic ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.5c01051.

Zelenectide pevedotin (BT8009) is a novel Bicycle Toxin Conjugate targeting nectin-4, designed to overcome the limitations of already existing anti-nectin-4 antibody-drug conjugates such as enfortumab ...

CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)-- Bicycle Therapeutics plc (NASDAQ: BCYC), a biopharmaceutical company pioneering a new and differentiated class of therapeutics based on its proprietary ...

Bicycle Therapeutics focuses on novel conjugated targeted therapies for cancer, with promising early results but no clear evidence of superior efficacy yet. Their lead compound, zelenectide pevedotin, ...

NEW YORK – Bicycle Therapeutics recently announced plans to develop the investigational agent zelenectide pevedotin in patients with NECTIN4 gene-amplified cancers, including breast and lung cancers.