Nonspecific major groove DNA-binding domains from both monomers embrace the DNA in a clamp-like structure. The interleaved nucleotide-binding sites are located far from the DNA.

Infomercial channels are riddled with the next-best hair-loss solution, but those toupees, ointments, and hair plugs might ...

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

The findings were published on January 7 in the journal Nucleic Acids Research in a paper titled "Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription ...

He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNA’s ...

When the Empire State Building was constructed, its 102 stories rose above midtown one piece at a time, with each individual element combining to become, for 40 years, the world's tallest building.

The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Imagine if you could "print" a tiny skyscraper using DNA instead of steel. That’s what researchers at Columbia and Brookhaven are doing—constructing intricate 3D nanostructures by harnessing the ...

Scientists at The Wistar Institute have discovered how a key protein from the Epstein-Barr virus (EBV), EBNA-LP, ...

Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying ...