Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

CAMBRIDGE, Mass., Feb. 13, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase ...

The three catalytic components of the pyruvate dehydrogenase complex, i.e., pyruvate dehydrogenase (E1, depicted in green), dihydrolipoamide acetyltransferase (E2, depicted in pink), and ...

4 Department of Pathology, Cruces University Hospital, Barakaldo, Spain 5 Ikerbasque, Basque Foundation for Science, Bilbao, Spain Background: Pyruvate dehydrogenase (PDH) complex converts pyruvate ...

In this global, phase 3, randomized, placebo-controlled trial, we evaluated the efficacy and safety of mitapivat in adults with pyruvate kinase deficiency who were not receiving regular red-cell ...

One well-known example is the replacement of the FeS cluster containing pyruvate:ferredoxin oxidoreductase (PFOR), which catalyzes the decarboxylation of pyruvate during fermentation in anaerobes, by ...

Decision letter after peer review: Thank you for submitting your article "Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria" for ...

Exogenous pyruvate plays a pivotal role in maintaining glycolysis–TCA cycle flux and ATP production under high-glucose conditions by suppressing PARP activity.

In this cellular model, the 13 C-isotopologue profiles of citrate and malate revealed that pyruvate decarboxylation to acetyl-CoA was preferred over pyruvate carboxylation to oxaloacetate by a factor ...