A small tweak to mitochondrial energy production led to big gains in health and longevity. Mice engineered to boost a protein that helps mitochondria work more efficiently lived longer and showed ...

Boosting mitochondrial calcium by inhibiting the LETM1 protein enhances long-term memory formation in flies and mice.

An international team led by Jaime de Juan-Sanz at the Paris Brain Institute has shown that slightly increasing the metabolic ...

The nuclear envelope (NE) is a dynamic and selective barrier that organizes genome function and nucleocytoplasmic communication, and its structural deterioration is a hallmark of aging associated with ...

The structural and functional characteristics of mitochondria shape their role as signaling organelles, with far-reaching effects regarding immune responses, inflammatory processes, and diseases. A ...

In a new study, researchers from Japan demonstrate that COX7RP, a mitochondrial protein, may play a key role in enhancing mitochondrial energy efficiency, leading not only to longer lifespans but also ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Mitochondrial dysfunctions are associated with a variety of pathologies, and the onset and progression of disease are accompanied by alterations in extracellular biochemical and mechanical signals.

This study reports a dynamic association/dissociation between malate dehydrogenase (MDH1) and citrate synthase (CIT1) in Saccharomyces cerevisiae under different ...

Streaming has undoubtedly changed how we watch movies. While nothing can replace the theatrical experience, the pros of streaming ultimately outweigh the cons. That being said, the prices are getting ...

The UK's pioneering licensed IVF technique to reduce the risk of mitochondrial diseases carried out in Newcastle has seen eight babies born, research shows. All eight babies show no signs of having ...

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying ...