The hydrophilic head of PDAs is easy to be chemically modified with functional ... By mixing diacetylene monomer 10,12-pentacosadiynoic acid and the polar brain lipid (contained phosphatidylinositol, ...

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States Graduate Group in Biophysics, University of California, San Francisco, San Francisco, United ...

Lipid nanoparticles (LNPs) represent a highly promising nonviral delivery platform for a variety of therapeutic nucleic acids, including short interfering RNA (siRNA), mRNA (mRNA), single-guide RNA ...

Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle's docking system and its counterpart on the station. Thanks to international ...

A few years ago, researchers at Carnegie Mellon University made an intriguing discovery: adding a branch to the end of LNPs' normally linear lipid tails dramatically improved mRNA delivery.

Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Yamaguchi 755-8611, Japan Department of Electrical and Mechanical Engineering, Graduate School of Engineering, Nagoya ...

Moreover, studies suggest that the lipid tail conferred by palmitoylation might support the peptide’s stability and bioavailability within experimental models, potentially making it a valuable tool in ...