The Jewett Lab has spent years reimagining biological processes to advance technological progress. Recently, the lab helped ...

Researchers built the Reductive Formate Pathway, called the ReForm pathway, to convert CO2 into acetyl-CoA outside living cells. Acetyl-CoA is a small but essential molecule your cells use to turn ...

What are the 4 steps of beta oxidation? Beta oxidation consists of the following four sequential reactions: 1- Acyl CoA, formed in the mitochondrial matrix, can be oxidized by the enzyme acyl CoA ...

Background: Emerging evidence suggests that the homeostasis of cytosolic acetyl-coenzyme A (acetyl-CoA) is critical for maintaining cardiac function, especially under pathological stress. Acetyl-CoA ...

Chinese researchers have revealed a mechanism that triggers metastasis of hepatocellular carcinoma (HCC)—the most common type of primary liver cancer—through the production of acetate by ...

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects in IVD function lead to toxic accumulation of metabolites such as isovaleric ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...

Rachel Raposas is a writer-reporter at PEOPLE, and has been working at PEOPLE since 2024. Madison E. Goldberg received her B.S. in Journalism and double minors in publishing and photography from ...

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a genetic condition that prevents the body from breaking down fat stores for energy. It can be fatal without early diagnosis and treatment.

Very long-chain acyl-CoA dehydrogenase deficiency (VLCAD), a rare inherited genetic condition, is caused by mutations in the ACADVL gene. It is associated with a disorder in fatty acid metabolism and ...