NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

The halfway mark of the NFL season is here! The Dallas Cowboys and Arizona Cardinals will wrap things up on Monday night in Week 9, but Sunday's slate was full

Although Sean McVay has created nearly continual success during his nine seasons in charge of the Los Angeles Rams, his team hasn’t looked this good at midseason since its Super Bowl championship run four years ago.

You've seen the model's best bets for New Orleans Saints vs. Los Angeles Rams. Now, get against the spread, total and money-line picks for every Week 9 NFL game here, all from the model that's simulated every game 10,000 times.

Watch full game highlights from the Los Angeles Rams vs. New Orleans Saints game in Week 9 of the 2025 NFL season.

The Colts have rushed for at least 120 yards in six of eight games, but the Rams held Indy to a season-low of 85 rushing yards. Jonathan Taylor’s league-best 850 rushing yards and 12 touchdowns, on pace for over 2,200 total yards, has him in the MVP conversation alongside Matthew Stafford.

It would have been disingenuous for the Los Angeles Rams to fall too far in the Week 9 power rankings following their Week 8 bye. The team actually "won" their week off, thanks to losses by other NFC contenders, made a small trade for a starting cornerback and got healthier with the impending returns of Puka Nacua and Rob Havenstein.

Alvin Kamara and the New Orleans Saints will face Puka Nacua and the Los Angeles Rams in Week 9 of the NFL season on Sunday.

With the trade deadline approaching, we're tracking all the latest rumors and news surrounding the Los Angeles Rams.