C&EN25d
Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition
Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States Department of Physics, University of Texas at Dallas, Richardson, Texas 75080, United ...
eLife4y
NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes
found that ribitol and ribose restored the ability of FKRP to add sugars to ... in FKRP-deficient zebrafish led to decreased muscle degeneration and improved muscle function when administered at ...
Frontiers4y
Mitochondria: Novel Mechanisms and Therapeutic Targets for Secondary Brain Injury After Intracerebral Hemorrhage
Moreover, mitochondria play an important role in promoting neuronal survival and improving neurological function after a hemorrhagic stroke. This review summarizes the mitochondrial mechanism involved ...
Frontiers5y
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+
Liver function tests consisted of serum ... Potential extracellular catabolism of exogenously supplied NAD+ through activity of ectoenzymes CD38 (ADP-ribose (ADPR) synthase), CD203a (NAD+ ...