The Red Devils are ready to accept a huge loss on the striker in the summer, with West Ham considering an offer.
Howe's side - who are in the Carabao Cup final for the second time in three years - will now play either Tottenham or Liverpool in the showpiece event on Sunday, March 16.
Jamie Carragher has named an increasingly common move that he believes should be 'banned' in the wake of Newcastle's second goal in their Carabao Cup semi-final against Arsenal.
Asked in a post-match interview whether injuries had played a part in Saturday's 1-0 loss, Wellens said: 'I'm not going to make excuses, I'm not Ange Postecoglou.' ...
The 31-year-old, who previously had a loan spell with the Turkish club, departs Molineux following two years after signing an 18-month contract in Istanbul with the option of an extra year.
Isak, who has repeatedly been linked with the Gunners in recent months, impressed against the visitor's defence duo of Gabriel Magalhaes and William Saliba during the semi-final.
Joao Felix scored on his debut and Tammy Abraham netted a double against his parent club to earn AC Milan a 3-1 win over AS Roma in their Coppa Italia quarter-final tie at the San Siro on Wednesday.
A Chelsea loanee scored on his AC Milan debut and Tammy Abraham added two more against his parent club to fire the hosts into the Coppa Italia semi-finals.
On the heels of a January transfer window that saw Arteta fail to add attacking firepower to his squad, Neville offered a brutal assessment of the north London side's fatal flaws on the night.
Arsenal are already with Bukayo Saka and Gabriel Jesus , with the latter having been ruled out for the season with an ACL injury.
Arteta's players will be forced to take stock after losing 4-0 on aggregate, their wait for a domestic trophy rolling on.
The 18-year-old played a starring role in Arsenal's win with the full back scoring the hosts third goal of the match, but his mum Marcia has admitted to missing his first professional strike.