CD22 Suppresses Microglial Phagocytosis—A New Therapeutic …
Apr 11, 2019 · CD22 popped up in screening for suppressors of microglial phagocytosis. The receptor is upregulated in aging mice and in Alzheimer’s. Blocking CD22 improves …
Associations of plasma soluble CD22 levels with brain
Apr 26, 2022 · Wyss-Coray and colleagues previously reported that microglia in aged mice express CD22, which functions as an inhibitory receptor of phagocytosis (Pluvinage et al., …
Could Targeting CD22 Restore Microglial Lysosome Trafficking?
Dec 8, 2021 · In human brain, CD22 is expressed in oligodendrocytes, its receptor on microglia. Binding of sCD22 to IGFR2 scrambles lysosomal trafficking, and lipids build up. Blocking this …
The CD22-IGF2R interaction is a therapeutic target for
Dec 8, 2021 · The most compelling observation in this study is the demonstration that disruption of the CD22-IGF2R interaction ameliorates lysosome dysfunction in human NPC1-mutant …
TdT (HT-6, 4KB128, UCHT1) - ALZFORUM
Jun 23, 2004 · Triple-Colour Reagent, Anti-Human TdT/FITC Anti-Human CD22/RPE Anti-Human CD3/APC; simultaneous detection and enumeration of T and B-lymphocyte precursor cells, B …
International Conference on Alzheimer's and Parkinson's
May 26, 2019 · Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- …
Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
Jun 30, 2020 · Further Reading News CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019 CD22 Suppresses Microglial Phagocytosis—A New …
Could CD33 Be the Microglial Target for Stimulating Phagocytosis?
Apr 23, 2019 · Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- …
2019—A Year of Hope for Alzheimer's Research - ALZFORUM
Jan 5, 2020 · CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019 'Runner Plasma' Jogs Neurogenesis, Quells Neuroinflammation in Mice 27 Sep 2019 …