Apr 29, 2024 · Imidazole - cas 288-32-4, synthesis, structure, density, melting point, boiling point

Imidazole (ImH) is an organic compound with the formula (CH) 3 (NH)N. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. It can be classified as a heterocycle , specifically as a diazole .

IDENTIFICATION AND USE: Imidazole, an organic alkaloid, is an important pharmacophore in drug discovery. Imidazole is used as a Karl Fischer reagent in analytical chemistry and a reagent in synthetic organic chemistry.

Jan 23, 2023 · Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature provides much information about the synthesis, functionalization, physicochemical characteristics and biological role of imidazole.

Imidazole, also known as Glyoxalin, is an aromatic heterocyclic diazole and a key biological buffer with a pH range of 6.2 to 7.8 at 25°C. It has a wide range of applications in molecular biology, biochemistry, and proteomics. In proteomics, imidazole is essential for eluting histidine-tagged proteins from IMAC columns.

Imidazole is used to treat cutaneous fungal infection, including candidiasis, dermatomycoses, pityriasis versicolor, and vaginal candidiasis. It acts by inhibiting 14-sterol-demethylase.

Tremendous advances in imidazole chemistry have been made in the decade since 1995, and are manifested in the large body of the literature related to imidazole and its analogs. This chapter reviews important developments in imidazole chemistry from 1996 to 2006.

The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of imidazole-derived compounds for treating incurable diseases.

Jun 13, 2005 · This compound belongs to the class of organic compounds known as imidazoles. These are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms. Kingdom Organic compounds Super Class Organoheterocyclic compounds Class Azoles Sub Class Imidazoles Direct ...

imidazole, any of a class of organic compounds of the heterocyclic series characterized by a ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions. The simplest member of the imidazole family is imidazole itself, a …