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Depakote or Divalproex sodium treats the mania of bipolar disorder, prevents attacks of migraine and reduces the frequency of epileptic seizures. For convenience two forms of Depakote exist with confusing names. The delayed release form must be taken two or three times a day while only one dose suffices of the extended release tablet ...
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Epilepsy (Generalized Tonic–Clonic Seizures) – Drug of Choice Tab. Sodium Valproate 500 mg PO BD Dose: Start 10–15 mg/kg/day, increase to 20–30 mg/kg/day in divided doses. Uses First-line drug for generalized tonic–clonic seizures. Also useful in myoclonic and absence seizures. Mechanism of Action ↑ GABA levels → enhances inhibitory transmission. Blocks voltage-gated sodium channels → stabilizes neuronal membranes. Blocks T-type calcium channels → suppresses abnormal discharges. Prescription Tab
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