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jove.com
Video: Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
325 Views. When a drug follows nonlinear pharmacokinetics, its bioavailability, the amount of the drug that reaches the systemic circulation, can change with different doses. This is due to the presence of a saturable pathway. The pathway becomes saturated as the drug concentration increases, decreasing the absorption rate. Consequently, the ...
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