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Is Lithium the Alzheimer’s Game-Changer? A new study published in Nature suggests that lithium levels in the brain may be a critical, early factor in Alzheimer’s disease — and that restoring lithium could reverse some of the damage.  Here’s what they found: • Lithium naturally exists in the brain, and in Alzheimer’s or mild cognitive impairment cases, it’s significantly depleted.  • One reason: amyloid-β plaques (hallmarks of Alzheimer’s) seem to bind or “trap” lithium, pulling it away from he
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Is Lithium the Alzheimer’s Game-Changer? A new study published in Nature suggests that lithium levels in the brain may be a critical, early factor in Alzheimer’s disease — and that restoring lithium could reverse some of the damage.  Here’s what they found: • Lithium naturally exists in the brain, and in Alzheimer’s or mild cognitive impairment cases, it’s significantly depleted.  • One reason: amyloid-β plaques (hallmarks of Alzheimer’s) seem to bind or “trap” lithium, pulling it away from he
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Rude Anatomy on Instagram: "🧠 Lithium is a true mood stabilizer for bipolar disorder Treats acute mania and provides long-term maintenance One of the few psychiatric meds shown to reduce death from self-harm, even independent of mood control Not a sedative Not a serotonin booster ⚠️ Narrow therapeutic window — levels matter Neurologic symptoms = think lithium toxicity Chronic use affects kidneys (polyuria, nephrogenic DI) and thyroid (hypothyroidism) Monitoring lithium levels, renal function, a
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Lithium has a very narrow therapeutic window, and small changes in kidney function or medications can quickly push levels into the toxic range. One of the most important clinical pearls is remembering the medications and conditions that reduce lithium clearance. A simple way to remember the major culprits is SALT. S – Sodium depletion: dehydration, vomiting, diarrhea, or low sodium intake cause the kidneys to conserve sodium. Because lithium is handled like sodium in the proximal tubule, the kid
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A recent mouse study on Alzheimer’s found that low lithium levels might actually play a role in neurodegeneration. When researchers gave the mice lithium orotate, many of the Alzheimer’s changes were reversed. It’s early and it’s in animals, but the research around lithium and cognition is getting really interesting! #BrainHealth #AlzheimersResearch #Neuroscience
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