Acute intermittent porphyria. | Ihab Suliman
Acute intermittent porphyria. | Ihab Suliman
6 days ago
linkedin.com
Code HAVIC @medschoolbro = Mystery Discount Acute Intermittent Porphyria (AIP) 🧩 Dx: AIP — porphobilinogen deaminase deficiency ⚡ Triggers: CYP-inducers (barbs, anti-seizures), fasting, alcohol, infections 🖐 5 P’s: Painful abdomen, Port-wine urine (darkens on standing), Polyneuropathy/paresthesias & weakness, Psych changes, Precipitated by drugs 🧪 Labs: ↑ ALA & PBG in urine; normal LFT/lipase/CT 💉 Tx (first-line): Hemin glucose → downregulates ALA-synthase 🚫 Avoid CYP inducers; stop offendi
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Video: Acute intermittent porphyria - Video Explanation! | Osmosis | Osmosis
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Acute hepatic porphyria is caused by defects in heme biosynthesis enzymes; the accumulation of neurotoxic heme intermediates causes injury to the nervous system and other organs. Attacks typically warrant urgent medical attention, and options for preventing attacks are limited. New research findings are summarized in a short video. https://nej.md/2MrQOmI | The New England Journal of Medicine
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